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Effects of β-Hydroxy-β-Methylbutyrate Supplementation on IL-4, IL-10 and TGF-β1 during Resistance Exercise in Athletes | ||
| Research in Exercise Nutrition | ||
| مقاله 2، دوره 1، شماره 1، تیر 2022، صفحه 15-21 اصل مقاله (558.12 K) | ||
| نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license | ||
| شناسه دیجیتال (DOI): 10.34785/J019.2022.524 | ||
| نویسندگان | ||
| Mohammad Rahman Rahimi* 1؛ Hamid Shoker-Nejad2 | ||
| 1Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran. | ||
| 2Master of exercise physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran. | ||
| چکیده | ||
| The aim of this study was to investigate the effect of β-Hydroxy-β-methylbutyrate (HMB) supplementation on anti-inflammatory cytokines including IL-4, IL-10 and TGF-β during an acute bout of resistance exercise (RE) in young resistance trained men. Ten resistance-trained men in a randomized, double-blind, placebo-controlled and crossover study, were administered a 7-day HMB supplementation (3×1 g.d-1 of HMB) and placebo (3×1 g.d-1 of Maltodextrin) with a 7 days washout period. After supplementation periods, subjects performed three sets of bench press, lat pull down, leg extension, leg curl, biceps curl, triceps curl and shoulder press to failure with 85% of one repetition to maximum (1RM). Blood samples were obtained before- (Pre), immediately post- (IP) and 1 hour-post RE (1h P) to assess serum concentrations of IL-4, IL-10 and TGF-β1. The data were analyzed using 2 (treatment: HMB and PL) × 3 (time points: Pre, IP and 1hP) repeated measures analysis of variance (ANOVA) followed by the Bonferroni post hoc test with a significant level of p<0.05. Serum IL-4 was significantly higher at IP resistance exercise in HMB compared to placebo. Circulating IL-4 and TGF-β1 were significantly raised at IP compared to Pre in both HMB and placebo treatments. No significant differences between treatments were observed for IL-10 and TGF-β1at any time points. In conclusion, HMB supplementation increased the circulating level of IL-4 during RE in resistance-trained men, which may attenuate inflammation and facilitate adaptation to RE. | ||
تازه های تحقیق | ||
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| کلیدواژهها | ||
| β-Hydroxy-β-Methylbutyrate؛ anti-inflamatory cytokines؛ resistance exercise | ||
| اصل مقاله | ||
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| مراجع | ||
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