Effects of aerobic training and Fed with High Fat Diet on Kiss1 , Kisspeptin receptor mRNA expression of Testis, LH and FSH in Adolescent male rats

[1] Palmer NO, Bakos HW, Fullston T, Lane M. Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis. 2012;2(4):253-63.

[2] Fullston T, Palmer N, Owens J, Mitchell M, Bakos H, Lane M. Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice. Human reproduction. 2012;27(5):1391-400.

[3]Hosseini B, Djafarian K. Dietary nutrients and male infertility: review of current evidence. Galen Medical Journal. 2015;4(4):123-29.

[4] Parsanezhad M, Jahromi B, Zare N, Keramati P, Khalili A, Parsa-Nezhad M. Epidemiology and etiology of infertility in Iran, systematic review and meta-analysis. J Womens Health, Issues Care. 2013;2(6):2.

[5] Kazemi A, Ghanbarzadeh M, Navidi Z, Soltani M. The effect of 8 weeks of intermittent exercise with consumption of black seed on serum levels of vaspin and lipid profile of obese women. Research in Exercise Nutrition. 2022;1(2):11-9.

[6] Rufus O, James O, Michael A. Male obesity and semen quality: Any association? International Journal of Reproductive BioMedicine. 2018;16(4):285.

[7] Hofny ER, Ali ME, Abdel-Hafez HZ, Kamal EE-D, Mohamed EE, El-Azeem HGA, et al. Semen parameters and hormonal profile in obese fertile and infertile males. Fertility and sterility. 2010;94(2):581-4.

[8] Al-Hameid SA, Zabbon AA, Saeed NAAA. Effect of obesity on some reproductive hormones in Iraqi men. Journal of Genetic and Environmental Resources Conservation. 2014;2(1):103-6.

[9] Davis JF, Choi DL, Schurdak JD, Fitzgerald MF, Clegg DJ, Lipton JW, et al. Leptin regulates energy balance and motivation through action at distinct neural circuits. Biological psychiatry. 2011;69(7):668-74.

[10] Cabler S, Agarwal A, Flint M, Du Plessis SS. Obesity: modern man's fertility nemesis. Asian journal of andrology. 2010;12(4):480.

[11] Reis LO, Dias FGF. Male fertility, obesity, and bariatric surgery. Reproductive sciences. 2012;19(8):778-85.

[12] d'Anglemont de Tassigny X, Colledge WH. The role of kisspeptin signaling in reproduction. Physiology. 2010;25(4):207-17.

[13] Dungan HM, Clifton DK, Steiner RA. Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006;147(3):1154-8.

[14] García‐Galiano D, Pinilla L, Tena‐Sempere M. Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions. Journal of neuroendocrinology. 2012;24(1):22-33.

[15] Jia Y-F, Guo Y, Zhou F, Zhang K-S, Wang X-W, Lu W-H, et al. Expression of kisspeptin-GnRH system is down-regulated in hypothalamic arcuate nucleus of male rats with high-fat-diet. Int J Clin Exp Pathol. 2017;10(5):6099-107.

[16] Sanchez-Garrido MA, Tena-Sempere M. Metabolic control of puberty: roles of leptin and kisspeptins. Hormones and behavior. 2013;64(2):187-94.

[17]         ZHAI L-l, ZHAO J, BAI Y-l. Department of Child and Adolescent Health, School of Public Health, China Medical University (Shenyang 110001, China); Relationship between change of sex hormone and reproductive dysfunction caused by obesity in mice [J]. 中国公共卫生. 2011;2.

[18]         Brown R, Imran S, Ur E, Wilkinson M. KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake. Molecular and cellular endocrinology. 2008;281(1-2):64-72.

[19]         Luque RM, Kineman RD, Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology. 2007;148(10):4601-11.

[20] Wahab F, Atika B, Shahab M. Kisspeptin as a link between metabolism and reproduction: evidences from rodent and primate studies. Metabolism. 2013;62(7):898-910.

[21]         Srinivasan K, Viswanad B, Asrat L, Kaul C, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacological research. 2005;52(4):313-20.

[22] Ibáñez CA, Erthal RP, Ogo FM, Peres MN, Vieira HR, Conejo C, et al. A high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise. Frontiers in physiology. 2017;8:807.

[23]         Hohos NM, Skaznik-Wikiel ME. High-fat diet and female fertility. Endocrinology. 2017;158(8):2407-19.

[24] Teerds K, De Rooij D, Keijer J. Functional relationship between obesity and male reproduction: from humans to animal models. Human reproduction update. 2011;17(5):667-83.

[25] Martino NA, Rizzo A, Pizzi F, Dell'Aquila ME, Sciorsci RL. Effects of kisspeptin-10 on in vitro proliferation and kisspeptin receptor expression in primary epithelial cell cultures isolated from bovine placental cotyledons of fetuses at the first trimester of pregnancy. Theriogenology. 2015;83(6):978-87.e1.

[26]         Stubbs RJ, Hughes DA, Johnstone AM, Whybrow S, Horgan GW, King N, et al. Rate and extent of compensatory changes in energy intake and expenditure in response to altered exercise and diet composition in humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2004;286(2):R350-R8.

[27]         Whybrow S, Hughes DA, Ritz P, Johnstone AM, Horgan GW, King N, et al. The effect of an incremental increase in exercise on appetite, eating behaviour and energy balance in lean men and women feeding ad libitum. British Journal of Nutrition. 2008;100(5):1109-15.

[28] Ghanbari-Niaki A, Saeidi A, Tartibian B, Qujeq D, Qomi MN. The Response of Brain Kisspeptin and Glycogen at Different Times to Acute Aerobic Exercise with and Without Glucose Solution Consumption in Male Rats. Journal of Clinical Research in Paramedical Sciences. 2018;7(2).

[29]         Uenoyama Y, Pheng V, Tsukamura H, Maeda K-i. The roles of kisspeptin revisited: inside and outside the hypothalamus. Journal of Reproduction and Development. 2016.

[30]         Castellano J, Gaytan M, Roa J, Vigo E, Navarro V, Bellido C, et al. Expression of KiSS-1 in rat ovary: putative local regulator of ovulation? Endocrinology. 2006;147(10):4852-62.

[31]         Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Kawaminami M. Augmentation of metastin/kisspeptin mRNA expression by the proestrous luteinizing hormone surge in granulosa cells of rats: implications for luteinization. Biology of reproduction. 2015;93(1):15, 1-9.

[32]         Ricu MA, Ramirez VD, Paredes AH, Lara HE. Evidence for a celiac ganglion-ovarian kisspeptin neural network in the rat: intraovarian anti-kisspeptin delays vaginal opening and alters estrous cyclicity. Endocrinology. 2012;153(10):4966-77.

[33]         Fernandois D, Na E, Cuevas F, Cruz G, Lara H, Paredes A. Kisspeptin is involved in ovarian follicular development during aging in rats. The Journal of endocrinology. 2016;228(3):161-70.

[34] Pinto F, Cejudo‐Román A, Ravina C, Fernández‐Sánchez M, Martín‐Lozano D, Illanes M, et al. Characterization of the kisspeptin system in human spermatozoa. International journal of andrology. 2012;35(1):63-73.

[35]         Calder M, Chan Y-M, Raj R, Pampillo M, Elbert A, Noonan M, et al. Implantation failure in female Kiss1−/− mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factor. Endocrinology. 2014;155(8):3065-78.

[36]         Feng T, Bai JH, Xu XL, Liu Y. Kisspeptin and its Effect on Mammalian Spermatogensis. Current drug metabolism. 2019;20(1):9-14.

[37]         Escobar S, Felip A, Zanuy S, Carrillo M. Is the kisspeptin system involved in responses to food restriction in order to preserve reproduction in pubertal male sea bass (Dicentrarchus labrax)? Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2016;199:38-46.

[38] Castellano JM, Bentsen AH, Mikkelsen JD, Tena-Sempere M. Kisspeptins: Bridging energy homeostasis and reproduction. Brain Research. 2010;1364:129-38.

[39]         Xu R, Yan Y, Xie M. The Affect Of Exercise On Hypothalamic Kiss-1 And Gpr54 In The Puberty Development Of Male Rats: 1936 Board# 197 May 31 200 PM-330 PM. Medicine & Science in Sports & Exercise. 2018;50(5S):467.

[40] George JT, Millar RP, Anderson RA. Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology. 2010;91(4):302-7.

[41] Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, et al. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes. 2006;55(9):2602-10.

[42]         Zhai L, Zhao J, Zhu Y, Liu Q, Niu W, Liu C, et al. Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity. Endocrine. 2018;62(1):195-206.

[43]         Jia Y-F, Guo Y, Zhou F, Zhang K-S, Wang X-W, Lu W-H, et al. Expression of kisspeptin-GnRH system is down-regulated in hypothalamic arcuate nucleus of male rats with high-fat-diet. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2017;10(5):6099-107.

[44]         Hofmann T, Elbelt U, Haas V, Ahnis A, Klapp BF, Rose M, et al. Plasma kisspeptin and ghrelin levels are independently correlated with physical activity in patients with anorexia nervosa. Appetite. 2017;108:141-50.

[45]         Abdel-Fadeil MR, Abd Allah ESH, Iraqy HM, Elgamal DA, Abdel-Ghani MA. Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin. Pathophysiology. 2019.

[46] Dudek M, Kołodziejski PA, Pruszyńska-Oszmałek E, Sassek M, Ziarniak K, Nowak KW, et al. Effects of high-fat diet-induced obesity and diabetes on Kiss1 and GPR54 expression in the hypothalamic–pituitary–gonadal (HPG) axis and peripheral organs (fat, pancreas and liver) in male rats. Neuropeptides. 2016;56:41-9.

[47] Loucks A, Heath E. Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women. The Journal of Clinical Endocrinology & Metabolism. 1994;78(4):910-5.

[48] Hussain MA, Abogresha NM, Hassan R, Tamany DA, Lotfy M. Effect of feeding a high-fat diet independently of caloric intake on reproductive function in diet-induced obese female rats. Archives of medical science : AMS. 2016;12(4):906-14.