Aim: This study investigates the effect of L-arginine supplementation on VEGF and endostatin responses during a session of Bruce exhaustive protocol in wrestlers.
Method: Fifteen wrestlers, with a mean age of 21.13±2.47 years and a body mass index of 24.1±2.3 kg/m², were selected through voluntary and purposive sampling and randomly assigned to two groups: supplement (n=8) and placebo (n=7). In both the pre-test and post-test, subjects performed the Bruce exhaustive protocol until exhaustion, and blood samples were taken before and immediately after the protocol. Subjects in the supplement group received L-arginine supplementation (0.1 g/kg body weight) for 45 days, while the placebo group received maltodextrin. Both groups continued their specialized training during the supplementation period as in previous weeks. Serum VEGF and endostatin levels were measured using ELISA. Statistical analysis of the data was performed using paired and independent t-tests.
Results: Changes in VEGF, endostatin, and the VEGF to endostatin ratio in wrestlers after a period of arginine supplementation and following a session of the Bruce exhaustion test were not statistically significant (P > 0.05).
Conclusion: Although the findings of this study were not statistically significant, it appears that L-arginine supplementation, with a relative increase in VEGF and the VEGF to endostatin ratio, and a decrease in endostatin in the supplementation group, may contribute to the development of the angiogenesis process. |
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