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The effect of high-intensity interval training and ginger supplementation on poly ADP-ribose polymerase 1 (PARP-1) and sirtuin 1 (SIRT1) gene expression in male rats with nonalcoholic fatty liver disease | ||
| Research in Exercise Nutrition | ||
| دوره 4، شماره 1، خرداد 2025، صفحه 74-61 اصل مقاله (802.18 K) | ||
| نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license | ||
| شناسه دیجیتال (DOI): 10.22034/ren.2025.143968.1112 | ||
| نویسندگان | ||
| Yaser Fakhraei؛ Sadegh Cheragh Birjandi* ؛ Ali Yaghoubi؛ Najmeh Rezaeian؛ Vahid Rezaei | ||
| Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran. | ||
| چکیده | ||
| Aim: The aim of the present study was to investigate the effect of high-intensity interval training and ginger supplementation on poly ADP-ribose polymerase 1 (PARP-1) and sirtuin 1 (SIRT1) gene expression in male mice with nonalcoholic fatty liver disease. Method: Twenty-five adult male Wistar rats, six weeks old and weighing 160±25 grams, were randomly selected and placed on a high-fat diet for 12 weeks to induce nonalcoholic fatty liver disease. The rats were then divided into five groups: healthy control, fatty liver control, exercise, ginger supplementation, and exercise + ginger supplementation. After confirmation of nonalcoholic fatty liver disease, ginger supplementation was administered daily and intense interval training was administered to the relevant groups for 8 weeks, 5 sessions per week. Real Time-PCR was used to measure PARP-1 and SIRT1 gene expression. Results: The expression of the PARP-1 gene in the exercise, ginger supplement, and exercise and ginger supplement groups was significantly reduced compared to the fatty liver control group (P=0.001). The expression of this gene in the fatty liver control group was also significantly increased compared to the healthy control group (P=0.001). The expression of the SIRT1 gene was also significantly increased compared to the fatty liver control group in the exercise, ginger supplement, and exercise and ginger supplement groups (P=0.001). The expression of this gene in the fatty liver control group was also significantly reduced compared to the healthy control group (P=0.001). No significant difference was observed between the experimental groups (P>0.05). Conclusion: High-intensity interval training combined with ginger supplementation resulted in decreased PARP-1 and increased SIRT1 in male rats with nonalcoholic fatty liver disease. These changes appear to be effective in improving the severity of the disease. | ||
| کلیدواژهها | ||
| High-intensity interval training؛ Zingiber Officinale Roscoe؛ Nonalcoholic fatty liver disease؛ PARP-1؛ SIRT1 | ||
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آمار تعداد مشاهده مقاله: 369 تعداد دریافت فایل اصل مقاله: 38 |
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