دومین نسخه چاپی مجله فصلنامه مطالعات ادبی و فرهنگی معاصر
آیین نامه نشریات علمی مصوب اردیبهشت ۱۳۹۸
شیوه نامه ارزیابی و رتبه بندی نشریات علمی

  اخبار و اعلانات

 آمار

تعداد نشریات34
تعداد شماره‌ها450
تعداد مقالات4,277
تعداد مشاهده مقاله6,417,309
تعداد دریافت فایل اصل مقاله6,366,241
Paykari, Somaye, Rahimi, Alireza, Aghaei, Fariba, Feizolahi, Fuad. (1404). Concurrent Effects of High-intensity Interval Training and Mealworm on Oxidative Stress, Muscle Mass, and Hepatic Fat and Glucose Metabolism in Rats with Non-Alcoholic Fatty Liver Disease. , 4(3), 11-24. doi: 10.22034/ren.2025.144426.1123
Somaye Paykari; Alireza Rahimi; Fariba Aghaei; Fuad Feizolahi. "Concurrent Effects of High-intensity Interval Training and Mealworm on Oxidative Stress, Muscle Mass, and Hepatic Fat and Glucose Metabolism in Rats with Non-Alcoholic Fatty Liver Disease". , 4, 3, 1404, 11-24. doi: 10.22034/ren.2025.144426.1123
Paykari, Somaye, Rahimi, Alireza, Aghaei, Fariba, Feizolahi, Fuad. (1404). 'Concurrent Effects of High-intensity Interval Training and Mealworm on Oxidative Stress, Muscle Mass, and Hepatic Fat and Glucose Metabolism in Rats with Non-Alcoholic Fatty Liver Disease', , 4(3), pp. 11-24. doi: 10.22034/ren.2025.144426.1123
Paykari, Somaye, Rahimi, Alireza, Aghaei, Fariba, Feizolahi, Fuad. Concurrent Effects of High-intensity Interval Training and Mealworm on Oxidative Stress, Muscle Mass, and Hepatic Fat and Glucose Metabolism in Rats with Non-Alcoholic Fatty Liver Disease. , 1404; 4(3): 11-24. doi: 10.22034/ren.2025.144426.1123

Concurrent Effects of High-intensity Interval Training and Mealworm on Oxidative Stress, Muscle Mass, and Hepatic Fat and Glucose Metabolism in Rats with Non-Alcoholic Fatty Liver Disease

Research in Exercise Nutrition
دوره 4، شماره 3، آذر 2025، صفحه 11-24    اصل مقاله (1.8 M)
نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license
شناسه دیجیتال (DOI): 10.22034/ren.2025.144426.1123
نویسندگان
Somaye Paykari1؛ Alireza Rahimi* 2؛ Fariba Aghaei1؛ Fuad Feizolahi1
1Department of Exercise Physiology, Ka.C., Islamic Azad University, Karaj, Iran
2Department of Exercise Physiology, Ka.C., Islamic Azad University, Karaj, Iran
چکیده
Aims: The present study aimed to evaluate the combined effects of aerobic exercise and Mealworm supplementation on reduced glutathione, hydrogen sulfide, lipid profile, glucose levels, and muscle mass in rats with non-alcoholic fatty liver disease (NAFLD).

Method: 25 male Wistar rats were randomly assigned to five equal groups: healthy, patient, patient + supplement, patient + exercise, and patient + supplement + exercise. Non-alcoholic fatty liver disease was induced by a high-fat and high-cholesterol diet. High-intensity interval aerobic training was performed for 8 weeks, 30 minutes, 5 days a week, at an intensity equivalent to 50-80% of maximum oxygen consumption, in a progressive overload manner. Mealworm supplement was administered via gavage at a dose of 20 mg/kg body weight. Enzymatic concentrations of reduced glutathione and hydrogen sulfide in the soleus muscle, sarcomere length and count, and serum levels of triglycerides, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), glucose, and body weight were measured. Data were analyzed using independent t-tests and two-way ANOVA at a significance level of P ≤ 0.05.

Results:NAFLD significantly altered the studied parameters. Both aerobic exercise and Mealworm supplementation independently led to significant reductions in hydrogen sulfide, triglycerides, cholesterol, LDL, glucose, and body weight, along with significant increases in reduced glutathione, HDL, and muscle mass. The combined intervention produced significant improvements in all measured variables except sarcomere length.

Conclusion:Aerobic exercise combined with Mealworm supplementation may play a crucial role in reducing insulin resistance and managing NAFLD by improving oxidative stress status and regulating hepatic lipid and glucose metabolism.

تازه های تحقیق

Given that aerobic exercise and mealworm supplementation, both independently and interactively, produced favorable changes in lipid profile, blood glucose, and antioxidant and oxidative stress indices in NAFLD, it appears that moderate‑intensity interval aerobic training combined with mealworm extract may play a substantial role in reducing insulin resistance and improving NAFLD through the enhancement of oxidative stress status and the regulation of hepatic lipid and glucose metabolism.

کلیدواژه‌ها
Aerobic Exercise؛ Mealworm؛ Glutathione؛ Lipid Profile
مراجع
  • [1] Gofton C, Upendran Y, Zheng M-H, George J. MAFLD: How is it different from NAFLD? Clinical and Molecular Hepatology. 2022;29(Suppl):S17. doi:3350/cmh.2022.0367
  • [2] Cigri E, ÇATAN İNAN F, Er E, Yildiz E. The relationship between lipid profile and non-alcoholic fatty liver disease in children and adolescents with obesity. Journal of the College of Physicians and Surgeons Pakistan. 2022;32(5).. doi:29271/jcpsp.2022.05.591
  • [3] Shishebori N, Fattahi Bafghi A, Hefzi J, Ebrahimi Z. The effect of 6 weeks of endurance training with berberine supplementation on the lipid profile of obese rats. Research in Exercise Nutrition. 2023;2(3):53-59., Doi: https://doi.org/10.22034/ren.2024.141351.1058
  • [4] Honda Y, Kessoku T, Sumida Y, Kobayashi T, Kato T, Ogawa Y, et al. Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology. 2017;17(1):96. doi:10.1186/s12876-017-0652-3
  • [5] Mateus I, Prip‐Buus C. Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease. European Journal of Clinical Investigation.2022;52(3):e13680.doi:10.1111/eci.13680
  • [6] Ma Y, Lee G, Heo S-Y, Roh Y-S. Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease. Antioxidants. 2021;11(1):91. 10.3390/antiox11010091
  • [7] Spahis S, Delvin E, Borys J-M, Levy E. Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis. Antioxidants & redox signaling. 2017;26(10):519-41. org/10.1089/ars.2016.6776
  • [8] Chakravarthy MV, Siddiqui MS, Forsgren MF, Sanyal AJ. Harnessing muscle–liver crosstalk to treat nonalcoholic steatohepatitis. Frontiers in Endocrinology. 2020;11:592373. e 11 – 2020. doi:10.3389/fendo.2020.592373
  • [9] Keshavarz F, Anoushirvani S, Arazi H, Afroundeh R, Golpasandi H. The effect of HIFT with ginger extract supplementation on the levels of some antioxidant enzymes in men with non-alcoholic fatty liver. Research in Exercise Nutrition. 2025;3(3):12-1. Doi: https://doi.org/10.22034/ren.2025.143126.1081
  • [10] Evangelista FS, Ferreira MM, Fortunato‐Lima VC, Correa SM, Vecchiatto B, Martucci LF, et al. Metabolic Cooperation Between Adipose Tissue and Skeletal Muscle Mediates the Prevention of NAFLD Through Aerobic Physical Exercise. The FASEB Journal. doi:10.1096/fasebj.2022.36.S1.R3228
  • [11] Ruan L, Wang G, Qing Lv Z, Li S, Liu Q, Ren Y, et al. The effect of varied exercise intensity on antioxidant function, aortic endothelial function, and serum lipids in rats with non-alcoholic fatty liver disease. Investigación Clínica. 2022;63(4):327-43. doi:10.54817/ic.v63n4a01
  • [12] Wang B, Zeng J, Gu Q. Exercise restores bioavailability of hydrogen sulfide and promotes autophagy influx in livers of mice fed with high-fat diet. Canadian Journal of Physiology and Pharmacology. 2017;95(6):667-74. doi:10.1139/cjpp-2016-0611
  • [13] Naghizadeh H. The effect of eight weeks of endurance training with alkaline water consumption on antioxidant status and lipid peroxidation in inactive obese men. Research in Exercise Nutrition. 2023;1(4):49-60. doi:22034/ren.2023.140207.1042
  • [14] Caldas BV, Guimarães VHD, Ribeiro GHM, dos Santos TAX, Nobre DA, de Castro RJS, et al. Effect of dietary supplementation withTenebrio molitor wholemeal and fermented flour modulating adipose lipogenesis gene expression in obese mice. Journal of Insects as Food and Feed. 2023;9(5):625-36. doi:10.3920/JIFF2022.0070
  • [15] Lee JY, Im A-R, Shim KS, Ji K-Y, Kim KM, Kim YH, Chae S. Beneficial effects of insect extracts on nonalcoholic fatty liver disease. Journal of Medicinal Food. 2020;23(7):760-71. doi:10.1089/jmf.2019.4536
  • [16] Ringseis R, Peter L, Gessner DK, Meyer S, Most E, Eder K. Effect of Tenebrio molitor larvae meal on the antioxidant status and stress response pathways in tissues of growing pigs. Archives of Animal Nutrition. 2021;75(4):237-50. doi:10.1080/1745039X.2021.1950106
  • [17] Cho H-R, Lee S-O. Novel hepatoprotective peptides derived from protein hydrolysates of mealworm (Tenebrio molitor). Food Research International. 2020;133:109194. doi:1016/j.foodres.2020.109194
  • [18] Park BM, Lim HJ, Lee BJ. Anti-obesity effects of Tenebrio molitor larvae powder in high-fat diet-induced obese mice. Journal of Nutrition and Health. 2021;54(4):342-54. doi:10.4163/jnh.2021.54.4.342
  • [19] Han J, Choi S-Y, Choi R-Y, Park K-W, Kang K-Y, Lee M-K. Anti-muscle atrophy effect of fermented Tenebrio molitor larvae extract by modulating the PI3K-Akt-mTOR/FoxO3α pathway in mice treated with dexamethasone. Biomedicine & Pharmacotherapy. 2024;178:117266. doi:10.1016/j.biopha.2024.117266
  • [20] Vangsoe MT, Joergensen MS, Heckmann L-HL, Hansen M. Effects of insect protein supplementation during resistance training on changes in muscle mass and strength in young men. Nutrients. 2018;10(3):335. doi:10.3390/nu10030335
  • [21] Wang DQ-H, Schmitz F, Kopin AS, Carey MC. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. The Journal of clinical investigation.2004;114(4):521-8. doi:10.1172/JCI16801
  • [22] Efati M, Khorrami M, Zarei MA, SARSHOORI R. Induction of an animal model of non-alcoholic fatty liver disease using a formulated high-fat diet. 2016.
  • [23] Li J, Huang L, Xiong W, Qian Y, Song M. Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway. Biochemical and Biophysical Research Communications. 2022;603:35-40. doi:10.1016/j.bbrc.2022.03.008
  • [24] Özçatal Y, Akat F, Tatar Y, Fıçıcılar H, Serdaroğlu B, Çelikkan FT, Baştuğ Effects of high-intensity interval training (HIIT) on skeletal muscle atrophy, function, and myokine profile in diabetic myopathy. Cytokine. 2023;169:156279doi:10.1016/j.cyto.2023.156279
  • [25] Payne CL, Scarborough P, Rayner M, Nonaka K. A systematic review of nutrient composition data available for twelve commercially available edible insects, and comparison with reference values. Trends in Food Science & Technology. 2016;47:69-77. doi:10.1016/j.tifs.2015.10.012
  • [26] Zhang Y, Cao C, Li C, Witt RG, Huang H, Tsung A, Zhang Physical exercise in liver diseases. Hepatology. 2024:10.1097. doi:10.1097/HEP.0000000000000941
  • [27] Takahashi H, Kotani K, Tanaka K, Egucih Y, Anzai K. Therapeutic approaches to nonalcoholic fatty liver disease: exercise intervention and related mechanisms. Frontiers in endocrinology. 2018 Oct 15;9:588. doi:10.3389/fendo.2018.00588
  • [28] Fakhraei Y, Cheragh Birjandi S, Yaghoubi A, Rezaeian N, Rezaei V. The effect of high-intensity interval training and ginger supplementation on poly ADP-ribose polymerase 1 (PARP-1) and sirtuin 1 (SIRT1) gene expression in male rats with nonalcoholic fatty liver disease. Research in Exercise Nutrition. 2025;4(1):74-61. https://doi.org/10.22034/ren.2025.143968.1112
  • [29] Witherspoon M, Sandu D, Lu C, Wang K, Edwards R, Yeung A, et al. ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. Oncotarget. 2019;10(40):4004. doi:18632/oncotarget.26958
  • [30] Irawati NAV, Sylviana N, Lubis L. Role of exercise intensity in skeletal muscle hypertrophy. Jurnal Biomedika dan Kesehatan. 2024;7(1):124-32. doi:10.18051/JBiomedKes.2024.v7.124-132
  • [31] Seo M, Goo T-W, Chung MY, Baek M, Hwang J-S, Kim M-A, Yun E-Y. Tenebrio molitor larvae inhibit adipogenesis through AMPK and MAPKs signaling in 3T3-L1 adipocytes and obesity in high-fat diet-induced obese mice. International Journal of Molecular Sciences. 2017;18(3):518. doi:10.3390/ijms18030518
  • [32] Jang HA, Lee SJ, Ku SM, Kim JH, Kang DW, Choi SY, et al. In silico identification and expression analysis of glutathione S‐transferase in Tenebrio molitor. Entomological Research. 2024;54(4):e12720. doi:10.1111/1748-5967.12720
  • [33] Yoo J, Cho K, Hong J, Jang H, Chung Y, Kwon G, et al. Nutrient ileal digestibility evaluation of dried mealworm (Tenebrio molitor) larvae compared to three animal protein by-products in growing pigs. Asian-Australasian journal of animal sciences. 2018;32(3):387. doi:5713/ajas.18.0647
  • [34] Haus JM, Solomon TP, Kelly KR, Fealy CE, Kullman EL, Scelsi AR, et al. Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease. The Journal of Clinical Endocrinology & Metabolism. 2013;98(7):E1181-E8. doi:10.1210/jc.2013-1229
  • [35] Mun S-K, Jang CJ, Jo S, Park S-H, Sim HB, Ramos SC, et al. Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice. Animal Cells and Systems. 2024;28(1):340-52. doi:10.1080/19768354.2024.2374547
  • [36] Gibala MJ, Little JP, MacDonald MJ, Hawley JA. Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of physiology. 2012;590(5):1077. doi:10.1113/jphysiol.2011.224725
  • [37] Hermans WJ, Senden JM, Churchward-Venne TA, Paulussen KJ, Fuchs CJ, Smeets JS, et al. Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial. The American journal of clinical nutrition. 2021;114(3):934-44. doi:10.1093/ajcn/nqab115
  • [38] Kimball SR. Interaction between the AMP-activated protein kinase and mTOR signaling pathways. Medicine and science in sports and exercise. 2006;38(11):1958. doi:1249/01.mss.0000233796.16411.13

 

آمار
تعداد مشاهده مقاله: 254
تعداد دریافت فایل اصل مقاله: 51


سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب