پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 34 |
| تعداد شمارهها | 436 |
| تعداد مقالات | 4,126 |
| تعداد مشاهده مقاله | 5,924,379 |
| تعداد دریافت فایل اصل مقاله | 5,975,968 |
The effect of eight weeks of intense interval training combined with pomegranate juice supplementation on oxidative stress and caspase 3 in mice with colon cancer | ||
| Research in Exercise Nutrition | ||
| دوره 4، شماره 3، اسفند 2025 | ||
| نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license | ||
| شناسه دیجیتال (DOI): 10.22034/ren.2025.144198.1116 | ||
| نویسندگان | ||
| Nazila Dejbakhsh1؛ Homa Sheikhani Shahin* 2؛ Zahra Mosalinejad3؛ Leila Malaei1 | ||
| 1Master of Sports Nutrition, Shiraz Zand Institute of Higher Education, Shiraz, Iran | ||
| 2Assistant professor of sport physiology, Department of sport Science, Zand Higher Education Institute, shiraz, Iran | ||
| 3Assistant Professor of Exercise Physiology, Department of Exercise Sciences, Shiraz Zand Institute of Higher Education, Shiraz, Iran | ||
| چکیده | ||
| Aim: Understanding the molecular mechanisms involved in colon disease is crucial for the development of novel therapeutic interventions. The aim of the present study was to investigate the effect of eight weeks of high-intensity interval training combined with pomegranate juice supplementation on oxidative stress and caspase-3 in experimental mice with colon cancer. The statistical sample of the present study was 35 Balbi mice, 28 of which were divided into groups after ensuring the induction of colon cancer, (1) control-patient, (2) pomegranate juice supplement-patient, (3) exercise-patient, (4) pomegranate juice supplement + exercise-patient. Also, to investigate the effects of cancer induction on the research variables, 7 rats were considered as a healthy control group. The exercise group performed intense interval training for eight weeks. Pomegranate juice supplement was mixed with drinking water daily at a daily dose of 5% and fed to the mice. ROS levels were measured by ELISA and caspase-3 gene expression in colon tissue was measured by Real-time PCR. Oxidative stress in the exercise+supplement-patient group was significantly lower than in the control-patient group (P=0.02). Also, the level of oxidative stress in the control-patient group was significantly higher than in the healthy control group (P=0.003). In terms of the relative expression of caspase-3, the exercise+supplement-patient group was significantly higher than in the control-patient group (P=0.043). onclusion: The combined intervention of intense interval training with pomegranate juice consumption has a reducing effect on oxidative stress and increased caspase-3 levels in colon cancer compared to either exercise training or pomegranate juice supplementation | ||
| کلیدواژهها | ||
| intense interval training؛ pomegranate juice supplementation؛ oxidative stress؛ caspase 3؛ colon cancer | ||
| مراجع | ||
|
| ||
|
آمار تعداد مشاهده مقاله: 127 |
||