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Dadashpour Dabanlou, Hadiseh, Afroundeh, Roghayyeh, Sepehrzadeh, Sara. (1405). The effect of eight weeks of resveratrol supplementation on serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women. , 5(1), 29-38. doi: 10.22034/ren.2026.144955.1144
Hadiseh Dadashpour Dabanlou; Roghayyeh Afroundeh; Sara Sepehrzadeh. "The effect of eight weeks of resveratrol supplementation on serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women". , 5, 1, 1405, 29-38. doi: 10.22034/ren.2026.144955.1144
Dadashpour Dabanlou, Hadiseh, Afroundeh, Roghayyeh, Sepehrzadeh, Sara. (1405). 'The effect of eight weeks of resveratrol supplementation on serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women', , 5(1), pp. 29-38. doi: 10.22034/ren.2026.144955.1144
Dadashpour Dabanlou, Hadiseh, Afroundeh, Roghayyeh, Sepehrzadeh, Sara. The effect of eight weeks of resveratrol supplementation on serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women. , 1405; 5(1): 29-38. doi: 10.22034/ren.2026.144955.1144

The effect of eight weeks of resveratrol supplementation on serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women

Research in Exercise Nutrition
مقاله 4، دوره 5، شماره 1، خرداد 2026، صفحه 29-38    اصل مقاله (1.37 M)
نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license
شناسه دیجیتال (DOI): 10.22034/ren.2026.144955.1144
نویسندگان
Hadiseh Dadashpour Dabanlou1؛ Roghayyeh Afroundeh* 2؛ Sara Sepehrzadeh1
1Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, university of Mohaghegh Ardabili, Ardabil, Iran.
2Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
چکیده
Aim: The aim of the present study was to investigate the effect of eight weeks of resveratrol supplementation on serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women.
Method: In this study, 20 obese women with a mean ± SD of weight of 87.8±4.25 kg, body mass index of 34.2±57 kg/m2, age of 29.85±3.04 years, height of 1.61±0.035 m, and fat percentage of 39.9±2.78 were selected through voluntary sampling and randomly divided into two supplement and control groups. Subjects in the supplement group took one 250 mg Quetrol Resveratrol capsule daily for eight weeks as a supplement. Before and after 8 weeks, a 5 cc blood sample was taken from the left brachial vein. Data were analyzed using analysis of covariance and paired t-test.
Results: To eliminate the pre-test effect in the post-test comparison of the two groups, the analysis of covariance statistical test was used. The results showed that there was a significant difference (p=0.001) between the groups for all variables in the post-test. Also, the results of the paired t-test showed that in the supplementation group, the post-test values of resistin (p=0.006), interleukin 1 beta (p=0.004) and TNF-α (p=0.002) decreased compared to the pre-test, and the values of sestrin 2 (p=0.01) increased compared to the pre-test.
Conclusion: Based on the findings of this study, it can be concluded that eight weeks of resveratrol supplementation improves the serum levels of resistin, interleukin 1 beta, sestrin 2 and TNF-α in inactive obese women.
کلیدواژه‌ها
Obesity؛ Interleukin 1 beta؛ Sestrin2؛ Resveratrol
مراجع
  • [1] Blueher M. An overview of obesity‐related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes. Diabetes, Obesity and Metabolism. 2025 Apr; 27:3-19. Doi: https://doi.org/10.1111/dom.16263
  • [2] Melson E, Ashraf U, Papamargaritis D, Davies MJ. What is the pipeline for future medications for obesity? Clinical Research. International Journal of Obesity. 2025 Mar;49(3):433-51. Doi: https://doi.org/10.1038/s41366-024-01473-y
  • [3] Gomez‐Casado G, Jimenez‐Gonzalez A, Rodriguez‐Muñoz A, Tinahones FJ, González‐Mesa E, Murri M, Ortega‐Gomez A. Neutrophils as indicators of obesity‐associated inflammation: A systematic review and meta‐ Obesity Reviews. 2025 Mar;26(3):e13868. Doi: https://doi.org/10.1111/obr.13868
  • [4] Man K, Kallies A, Vasanthakumar A. Resident and migratory adipose immune cells control systemic metabolism and thermogenesis. Cellular & molecular immunology. 2022 Mar;19(3):421-31. Doi: https://doi.org/10.1038/s41423-021-00804-7
  • [5] Kirichenko TV, Markina YV, Bogatyreva AI, Tolstik TV, Varaeva YR, Starodubova AV. The role of adipokines in inflammatory mechanisms of obesity. International journal of molecular sciences. 2022 Nov 29;23(23):14982. Doi: https://doi.org/10.3390/ijms232314982
  • [6] Gao K, Liu Y, Sun C, Wang Y, Bao H, Liu G, Ou J, Sun P. TNF-ɑ induces mitochondrial dysfunction to drive NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells. Scientific Reports. 2024 Oct 29;14(1):25880. Doi: https://doi.org/10.1038/s41598-024-76997-4
  • [7] Langhnoja J, Buch L, Pillai P. Neurotrophomodulatory effect of TNF-α through NF-κB in rat cortical astrocytes: Crosstalk between cytokine and neurotrophins. Cytotechnology. 2025 Feb;77(1):37. Doi: https://doi.org/10.1007/s10616-024-00698-z
  • [8] Castelli V, Kacem H, Brandolini L, Giorgio C, Scenna MS, Allegretti M, Cimini A, d’Angelo M. TNFα-CXCR1/2 partners in crime in insulin resistance conditions. Cell death discovery. 2024 Dec 3;10(1):486. Doi: https://doi.org/10.1038/s41420-024-02227-5
  • [9] Babaei S, Fattahpou marandi M. The effect of 12 weeks of aerobic training and zinc supplementation on interleukin 1 beta and TNF alpha in women with type 2 diabetes. Research in Exercise Nutrition. 2022;1(3):33-41. doi:10.22034/ren.2023.140130.1025
  • [10] Ghanbari M, Maragheh SM, Aghazadeh A, Mehrjuyan SR, Hussen BM, Shadbad MA, Dastmalchi N, Safaralizadeh R. Interleukin-1 in obesity-related low-grade inflammation: From molecular mechanisms to therapeutic strategies. International immunopharmacology. 2021 Jul 1;96:107765. Doi: https://doi.org/10.1016/j.intimp.2021.107765
  • [11] Huang Y, Cui Y, Huang J, Xinyuan H, Zihang W, Luo T, Li J. Proanthocyanidins protects 3-NPA-induced ovarian function decline by activating SESTRIN2-NRF2-mediated oxidative stress in mice. Scientific Reports. 2024 Oct 27;14(1):25643. Doi: https://doi.org/10.1038/s41598-024-76743-w
  • [12] Soylu Ustkoyuncu P, Kocer D. Sestrin-2 levels and insulin resistance in childhood obesity. Journal of Investigative Medicine. 2026 Apr;74(3):254-9. Doi: https://doi.org/10.1177/10815589251359311
  • [13] Tian J, Niu Z, Yang H, Wang C, Guan L, Zhao L, Shi D, Zhang Z. PERK/Sestrin2 signaling pathway mediated autophagy regulates human cardiomyocytes apoptosis induced by traffic-related PM2. 5 and diverse constituents. International Journal of Molecular Sciences. 2025 Apr 17;26(8):3784. Doi: https://doi.org/10.3390/ijms26083784
  • [14] Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell metabolism. 2012 Sep 5;16(3):311-21. Doi: https://doi.org/10.1016/j.cmet.2012.08.004
  • [15] Radeva L, Yoncheva K. Resveratrol—A promising therapeutic agent with problematic properties. Pharmaceutics. 2025 Jan 19;17(1):134. Doi: https://doi.org/10.3390/pharmaceutics17010134
  • [16] Shen F, Chen SJ, Dong XJ, Zhong H, Li YT, Cheng GF. Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells. Journal of Asian natural products research. 2003 Jun 1;5(2):151-7. Doi: https://doi.org/10.1080/1028602031000066852
  • [17] Yasmin T, Menon SN, Pandey A, Siddiqua S, Kuddus SA, Rahman MM, Khan F, Hoque N, Rana MS, Subhan N, Habibi E. Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways. Scientific Reports. 2025 Jul 11;15(1):25162. Doi: https://doi.org/10.1038/s41598-025-08450-z
  • [18] Alipour Ghazichaki N, Abdi A, Barari A. The Effect of Pilates Training with Resveratrol on Serum Levels of Sestrin 2, Lipocalin 2, Oxidative Stress and Metabolic Syndrome in Obese Middle-Aged Women. Journal of Applied Health Studies in Sport Physiology. 2023; 10(2): 94-109. doi: 10.22049/jahssp.2023.28394.1548
  • [19] Soliman AY, Elguindy NM, Saleh AM, Balbaa M. Biochemical and molecular evaluation of resveratrol and selenium nanoparticles in managing type 2 diabetes and its complications. Scientific Reports. 2025 Jul 15;15(1):25565.Doi: https://doi.org/10.1038/s41598-025-11156-x
  • [20] Esfahani FH, Asghari G, Mirmiran P, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran Lipid and Glucose Study. Journal of epidemiology. 2010 Mar 5;20(2):150-8. Doi: https://doi.org/10.2188/jea.je20090083
  • [21] Alipour Ghazichaki N, Abdi A, Barari A. The Effect of Pilates Training with Resveratrol on Serum Levels of Sestrin 2, Lipocalin 2, Oxidative Stress and Metabolic Syndrome in Obese Middle-Aged Women. Journal of Applied Health Studies in Sport Physiology. 2023 Sep 23;10(2):94-109.
  • [22] Seo K, Seo S, Han JY, Ki SH, Shin SM. Resveratrol attenuates methylglyoxal-induced mitochondrial dysfunction and apoptosis by Sestrin2 induction. Toxicology and applied pharmacology. 2014 Oct 15;280(2):314-22. Doi: https://doi.org/10.1016/j.taap.2014.08.011
  • [23] Jin SH, Yang JH, Shin BY, Seo K, Shin SM, Cho IJ, Ki SH. Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. Toxicology and applied pharmacology. 2013 Aug 15;271(1):95-105. Doi: https://doi.org/10.1016/j.taap.2013.04.023
  • [24] Riyahi Malayeri S, Azadniya A, Rasaee MJ. Effect of eight-week High intensity interval training and resveratrol intake on serum adiponectin and resistin in type 2 diabetic rats. Iranian Journal of Diabetes and Metabolism. 2019 Jan 10;18(1):8-1.
  • [25] Zarei S, Saidijam M, Karimi J, Yadegarazari R, Farimani AR, HOSSEINI-ZIJOOD SO, Goodarzi MT. Effect of resveratrol on resistin and apelin gene expressions in adipose tissue of diabetic rats. Turkish journal of medical sciences. 2016;46(5):1561-7. Doi: https://doi.org/10.3906/sag-1505-6
  • [26] Mercader J, Palou A, Bonet ML. Resveratrol enhances fatty acid oxidation capacity and reduces resistin and Retinol-Binding Protein 4 expression in white adipocytes. The Journal of nutritional biochemistry. 2011 Sep 1;22(9):828-34. Doi: https://doi.org/10.1016/j.jnutbio.2010.07.007
  • [27] Blander G, Guarente L. The Sir2 family of protein deacetylases. Annual review of biochemistry. 2004 Jul;73(1):417-35. Doi: https://doi.org/10.1146/annurev.biochem.73.011303.073651
  • [28] Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado de Oliveira R, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature. 2004 Jun 17;429(6993):771-6. Doi: https://doi.org/10.1038/nature02583
  • [29] Bastin A, Netticadan T, Abbasi F, Rahimi N, Mahmoodi M, Alizadeh M, Movahed A, Momeni-Moghaddam MA. Effects of resveratrol on inflammatory cytokines in COVID-19 patients: A randomized, double-blinded, placebo-controlled clinical trial. Molecular and Cellular Biochemistry. 2025 Aug;480(8):4865-72. Doi: https://doi.org/10.1007/s11010-025-05290-3
  • [30] Elmorsy EM, Al-Ghafari AB, Al Doghaither HA. Resveratrol Anti-inflammatory effect against Palmitate-induced cytotoxicity in Raw 264.7 macrophages. Current Medicinal Chemistry. 2025 Oct;32(33):7406-21. Doi: https://doi.org/10.2174/0109298673352457241210083325
  • [31] Malayeri SR, Abdolhay S, Behdari R, Hoseini M. The combined effect of resveratrol supplement and endurance training on IL-10 and TNF-α in type 2 diabetic rats.
  • [32] Wu B, Ma Y, Yi Z, Liu S, Rao S, Zou L, Wang S, Xue Y, Jia T, Zhao S, Shi L. Resveratrol-decreased hyperalgesia mediated by the P2X7 receptor in gp120-treated rats. Molecular pain. 2017 May;13:1744806917707667. Doi: https://doi.org/10.1177/1744806917707667
  • [33] Shakibaei M, Csaki C, Nebrich S, Mobasheri A. Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochemical pharmacology. 2008 Dec 1;76(11):1426-39. Doi: https://doi.org/10.1016/j.bcp.2008.05.029
  • Liu L, Gu H, Liu H, Jiao Y, Li K, Zhao Y, An L, Yang J. Protective effect of resveratrol against IL-1β-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-κB signaling pathway: an “in vitro study”. International journal of molecular sciences. 2014 Apr 22;15(4):6925-40.  Doi: https://doi.org/10.3390/ijms15046925
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