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Interactive Effect of Eight Weeks of Combined Training and Taurine Supplementation on the Expression of NLRP3 and IL-1β Genes in the Liver tissue of Male Diabetic Wistar Rats | ||
| Research in Exercise Nutrition | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 23 خرداد 1405 | ||
| نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license | ||
| شناسه دیجیتال (DOI): 10.22034/ren.2026.145665.1163 | ||
| نویسندگان | ||
| ameneh pourrahim* 1؛ mohammad babaei2؛ reza farzizadeh2؛ abolfazl bayrami3 | ||
| 1department of port physiology, he faculty of educational sciences and psychology.university of mohaghegh ardabili , ardabil .iran | ||
| 2Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran | ||
| 3Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran | ||
| چکیده | ||
| Aim: Diabetes is associated with low-grade inflammation. Controlling inflammatory factors as a therapeutic strategy has attracted much attention. The present study aimed to determine Interactive effect of eight weeks combined training and taurine supplementation on the expression of NLRP3 and IL-1β genes in the liver tissue of male diabetic Wistar rats. Method: In this experimental study, 40 male Wistar rats, 8 weeks old and weighing 233.20 ± 13.89 g, were randomly divided into four groups of 10 healthy controls, diabetic controls, diabetic + taurine, and diabetic exercise + taurine. After induction of type 1 diabetes, the diabetic exercise + taurine groups performed combined training for eight weeks, five days a week. Rats in the diabetic + taurine and diabetic exercise + taurine groups were injected intraperitoneally 100 mg/kg body weight taurine supplement for eight weeks. Real-Time PCR was used to measure the expression of genes. SPSS software version 24 was used to analyze the data. Results: Expression level of NLRP3 gene was significantly decreased in diabetic + taurine and diabetic exercise + taurine groups compared to diabetic control group (P=0.001). Expression level of IL-1β gene was significantly decreased in diabetic + taurine and diabetic exercise + taurine groups compared to diabetic control group (P=0.001). Conclusion: Induction of diabetes increased the expression of NLRP3 and IL-1β genes. Eight weeks of combined exercise and taurine consumption resulted in a decrease in the expression of the above inflammatory genes in the liver tissue of diabetic Rats. | ||
| کلیدواژهها | ||
| Diabetes؛ combined Training؛ taurine؛ NLRP3؛ IL-1β | ||
| مراجع | ||
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آمار تعداد مشاهده مقاله: 89 |
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