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Interactive Effect of Nanoliposomal Selenium and Resistance Training on FGF1 Gene Expression and Protein Concentration, SOD Activity, MDA Concentration in the Soleus Muscle and Motor Performance of Aged Rats | ||
| Research in Exercise Nutrition | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 مهر 1405 | ||
| نوع مقاله: Research Paper I Open Access I Released under (CC BY-NC 4.0) license | ||
| شناسه دیجیتال (DOI): 10.22034/ren.2026.145857.1166 | ||
| نویسندگان | ||
| Mehrdad Rahimzadeh* ؛ Amir Sarshin* ؛ Foad Feizollahi؛ Mohammad Ali Soleiman Fallah | ||
| Department of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran. | ||
| چکیده | ||
| Aim: This study aimed to investigate the interactive effect of nanoliposomal selenium and resistance training on FGF1 gene expression and protein concentration, SOD activity, MDA concentration in the soleus muscle, and motor performance of aged rats. Methods: Twenty male Wistar rats with a mean age of 20 months were randomly divided into four equal groups: aged control, aged + supplement, aged + training, and aged + supplement + training. Resistance training was performed for eight weeks, four sessions per week, and included climbing a resistance ladder with a load equivalent to 25% of body weight, three to five sets of 8–12 repetitions, with overload applied once every two weeks. Nanoliposomal selenium supplement at 2.5 mg/kg body weight was administered by gavage on training days after exercise. After completion of the research interventions, a functional test was performed to assess sensorimotor function and spontaneous physical activity. FGF1 gene expression was measured by real-time PCR, relative FGF1 protein concentration by Western blotting, and SOD activity and MDA concentration in the soleus muscle by enzymatic colorimetry. Data were analyzed using two-way ANOVA at P≤0.05. Results: Resistance training and nanoliposomal selenium supplementation, each independently, increased gene expression (P=0.010 for training and P=0.002 for supplementation), FGF1 protein concentration and SOD activity, improved motor performance, and reduced MDA concentration (P<0.001 for both interventions). The interaction of training and supplementation was significant for gene expression (P=0.013), FGF1 protein concentration (P=0.008), SOD activity (P=0.001), and MDA concentration (P=0.001). Conclusions: Resistance training and nanoliposomal selenium, independently and interactively, may counteract age-related muscle atrophy through modulation of oxidative stress; however, improvement in motor performance appears to be influenced by other regulatory pathways that the interaction of these two interventions was unable to activate synergistically. | ||
| کلیدواژهها | ||
| exercise؛ sodium selenite؛ aging؛ oxidative stress | ||
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